Other Names:. Eye diseases ; Nervous System Diseases. This disease is grouped under:. Summary Summary. Symptoms Symptoms. Within the first year of life, those affected with classic Pelizaeus-Merzbacher disease typically experience weak muscle tone hypotonia , involuntary movements of the eyes nystagmus , and delayed development of motor skills such as crawling or walking. As the child gets older, nystagmus may improve, but other movement disorders develop, including muscle stiffness spasticity , problems with movement and balance ataxia , and involuntary jerking choreiform movements.
Symptoms are usually present at birth or develop in the first few weeks of life. Features include nystagmus , problems feeding, a whistling sound when breathing, progressive spasticity leading to joint deformities contractures that restrict movement, speech difficulties dysarthria , ataxia, and seizures.
Those affected with connatal Pelizaeus-Merzbacher disease don't walk or develop effective use of their upper limbs. Verbal expression is usually severely affected, but comprehension may be significant. Showing of 52 View All. Involuntary, rapid, rhythmic eye movements. Behavioral changes. Behavioral disorders. Behavioral disturbances. Behavioral problems. Psychiatric disorders. Psychiatric disturbances. Wasting syndrome. Decrease in size of the outer layer of the brain due to loss of brain cells.
Loss of developmental milestones. Mental deterioration in childhood. Faltering weight in infancy. Weight faltering in infancy. Abnormal gait. Abnormal walk. Impaired gait. Stiff joint. Stiff joints. Hunched back. Round back. Low or weak muscle tone. Premature delivery of affected infants. Preterm delivery. Signs and symptoms worsen slowly with time. Involuntary muscle stiffness, contraction, or spasm. Impaired vision.
Loss of eyesight. Poor vision. Urinary tract abnormalities. Urinary tract abnormality. Urinary tract anomalies. Loss of bowel control. Deficiency of speech development. Delayed language development. Delayed speech. Delayed speech acquisition. Delayed speech development.
Impaired speech and language development. Impaired speech development. Language delay. Language delayed. Language development deficit. Late-onset speech development. Poor language development.
Speech and language delay. Speech and language difficulties. Speech delay. Difficulty articulating speech. Poor swallowing. Swallowing difficulties. Swallowing difficulty. Faltering weight. Weight faltering. Hearing defect. Mental deficiency. Mental retardation. Mental retardation, nonspecific. Abnormally small skull. Decreased circumference of cranium. Decreased size of skull. Reduced head circumference.
Small head circumference. Speech disorder. Speech impairment. Speech impediment. Frequent respiratory infections. Multiple respiratory infections. Susceptibility to respiratory infections. Respiratory impairment. Decreased body height. Small stature. Decreased reflex response. Decreased reflexes. Decreased muscle tone. There is nothing complicated about the process of downloading and it can be completed in just a few minutes. What are the reasons for choosing our online resource? There are plenty.
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